A Clinician's Guide to Celiac Disease HLA Genetics.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 31274511.
- Also identified by DOI 10.14309/ajg.0000000000000310.
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Abstract
Celiac disease is a common inflammatory disease triggered by dietary gluten in genetically susceptible individuals. The strongest and best-characterized genetic susceptibilities in celiac disease are class II human leukocyte antigen (HLA) genes known as HLA-DQ2 and DQ8. HLA genetic testing is available through a number of commercial and academic laboratories and is used in the evaluation of celiac disease and to identify at-risk family members. Importantly, HLA genetic testing has a high negative predictive value for celiac disease, but a low positive predictive value. Therefore, for a practicing clinician, it is important to understand when to order HLA genetic testing, what test to order, and how to interpret the result. This review provides a practical primer on HLA genetics in celiac disease.
Medical subject headings
- Celiac Disease
- Genetic Testing
- HLA-DQ Antigens
- Practice Guidelines as Topic