The transcription factor OsSUF4 interacts with SDG725 in promoting H3K36me3 establishment.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 31278262.
- Also identified by DOI 10.1038/s41467-019-10850-5 and PMC identifier 6611904.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
The different genome-wide distributions of tri-methylation at H3K36 (H3K36me3) in various species suggest diverse mechanisms for H3K36me3 establishment during evolution. Here, we show that the transcription factor OsSUF4 recognizes a specific 7-bp DNA element, broadly distributes throughout the rice genome, and recruits the H3K36 methyltransferase SDG725 to target a set of genes including the key florigen genes RFT1 and Hd3a to promote flowering in rice. Biochemical and structural analyses indicate that several positive residues within the zinc finger domain are vital for OsSUF4 function in planta. Our results reveal a regulatory mechanism contributing to H3K36me3 distribution in plants.
Medical subject headings
- Histone-Lysine N-Methyltransferase
- Histones
- Oryza
- Plant Proteins
- Trans-Activators