Targeting TGFβ Pathway in Adult Granulosa Cell Tumor: Opening Pandora's Box?
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 31296528.
- Also identified by DOI 10.1158/1078-0432.CCR-19-1605.
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Abstract
Adult granulosa cell tumor (AGCT) is a rare malignancy characterized by <i>FOXL2</i> (<i>C134W</i>) mutation, an inherent component of the TGFβ pathway. Activin A, a TGFβ superfamily member, is a driver of this activity and is a potential target in AGCT.<i>See related article by Tao et al., p. 5458</i>.
Medical subject headings
- Granulosa Cell Tumor
- Ovarian Neoplasms