Senescence Evasion in Chemotherapy: A Sweet Spot for p21.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 31299197.
- Also identified by DOI 10.1016/j.cell.2019.06.025 and PMC identifier 6805149.
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Abstract
Time-lapse imaging reveals a nuanced role for p21 in cancer cells challenged with chemotherapeutic drugs: cells with either high or low p21 are biased toward senescence, whereas intermediate p21 allows cells to re-enter the cell cycle after drug treatment.
Medical subject headings
- Cellular Senescence