Survivors of Ebola Virus Disease Develop Polyfunctional Antibody Responses.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 31301137.
- Also identified by DOI 10.1093/infdis/jiz364 and PMC identifier 7184900.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Monoclonal antibodies can mediate protection against Ebola virus (EBOV) infection through direct neutralization as well as through the recruitment of innate immune effector functions. However, the antibody functional response following survival of acute EBOV disease has not been well characterized. In this study, serum antibodies from Ebola virus disease (EVD) survivors from Sierra Leone were profiled to capture variation in overall subclass/isotype abundance, neutralizing activity, and innate immune effector functions. Antibodies from EVD survivors exhibited robust innate immune effector functions, mediated primarily by IgG1 and IgA1. In conclusion, development of functional antibodies follows survival of acute EVD.
Medical subject headings
- Antibodies, Neutralizing
- Antibodies, Viral
- Hemorrhagic Fever, Ebola
- Immunity, Innate
- Immunoglobulin G