Ultra high dose rate Synchrotron Microbeam Radiation Therapy. Preclinical evidence in view of a clinical transfer.

Eling, Laura; Bouchet, Audrey; Nemoz, Christian; Djonov, Valentin; Balosso, Jacques; Laissue, Jean; Bräuer-Krisch, Elke; Adam, Jean Francois et al. · Radiother Oncol · 2019

review · Level V

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Abstract

This paper reviews the current state of the art of an emerging form of radiosurgery dedicated to brain tumour treatment and which operates at very high dose rate (kGy·s<sup>-1</sup>). Microbeam Radiation Therapy uses synchrotron-generated X-rays which triggered normal tissue sparing partially mediated by FLASH effect.

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