New Functions of Long Noncoding RNAs during EMT and Tumor Progression.
editorial · Level V
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- Record sourced from PubMed, PMID 31308135.
- Also identified by DOI 10.1158/0008-5472.CAN-19-1205.
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Abstract
Epithelial-to-mesenchymal transition (EMT) is orchestrated by aberrant activation of EMT transcription factors and expression of downstream target genes resulting in increased tumor initiation, metastatic potential, and therapeutic resistance. In this issue of <i>Cancer Research</i>, Wang and colleagues show that the long noncoding RNA <i>SATB2</i>-<i>AS1</i> is dysregulated in colorectal carcinoma and correlates with poor survival and prognosis. They present a new functional mechanism illustrating how the <i>SATB2</i>-<i>AS1</i>-SATB2-Snail axis is involved in epigenetic modification that regulates colorectal carcinoma progression.<i>See related article by Wang et al., p. 3542</i>.
Medical subject headings
- RNA, Long Noncoding