Joint analysis of heterogeneous single-cell RNA-seq dataset collections.
basic_science · Level V
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- Record sourced from PubMed, PMID 31308548.
- Also identified by DOI 10.1038/s41592-019-0466-z and PMC identifier 6684315.
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Abstract
Single-cell RNA sequencing is often applied in study designs that include multiple individuals, conditions or tissues. To identify recurrent cell subpopulations in such heterogeneous collections, we developed Conos, an approach that relies on multiple plausible inter-sample mappings to construct a global graph connecting all measured cells. The graph enables identification of recurrent cell clusters and propagation of information between datasets in multi-sample or atlas-scale collections.
Medical subject headings
- Bone Marrow
- Computational Biology
- Databases, Genetic
- Gene Expression Profiling
- High-Throughput Nucleotide Sequencing
- Single-Cell Analysis