A genetically encodable cell-type-specific protein synthesis inhibitor.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 31308551.
- Also identified by DOI 10.1038/s41592-019-0468-x.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Chemical inhibitors have revealed requirements for protein synthesis that drive cellular plasticity. We developed a genetically encodable protein synthesis inhibitor (gePSI) to achieve cell-type-specific temporal control of protein synthesis. Controlled expression of the gePSI in neurons or glia resulted in rapid, potent and reversible cell-autonomous inhibition of protein synthesis. Moreover, gePSI expression in a single neuron blocked the structural plasticity induced by single-synapse stimulation.
Medical subject headings
- Genetic Engineering
- Hippocampus
- Neuronal Plasticity
- Neurons
- Protein Biosynthesis
- Protein Synthesis Inhibitors
- Synapses