Cerebellar disruption impairs working memory during evidence accumulation.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 31311934.
- Also identified by DOI 10.1038/s41467-019-11050-x and PMC identifier 6635393.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
To select actions based on sensory evidence, animals must create and manipulate representations of stimulus information in memory. Here we report that during accumulation of somatosensory evidence, optogenetic manipulation of cerebellar Purkinje cells reduces the accuracy of subsequent memory-guided decisions and causes mice to downweight prior information. Behavioral deficits are consistent with the addition of noise and leak to the evidence accumulation process. We conclude that the cerebellum can influence the accurate maintenance of working memory.
Medical subject headings
- Cerebellum
- Decision Making
- Memory, Short-Term