Monocyte Dysfunction, Activation, and Inflammation After Long-Term Antiretroviral Therapy in an African Cohort.
cross_sectional · Level IV
Where this comes from
- Record sourced from PubMed, PMID 31323092.
- Also identified by DOI 10.1093/infdis/jiz320 and PMC identifier 6761975.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Monocyte dysfunction may persist during antiretroviral therapy (ART). Frozen peripheral blood mononuclear cells of 30 human immunodeficiency virus (HIV)-infected ART-treated adults with sustained viral suppression and CD4 counts ≥500 cells/µL were consecutively analyzed for monocyte phenotypes and function. Nonclassical monocytes (CD14+, CD16++), interleukin (IL)-1β production, and expression of CD40 and CD86 were lower among ART-treated HIV-infected adults relative to age-matched HIV-negative adults (P = .01, P = .01, and P = .02, respectively). Intestinal fatty acid-binding protein, IL6, and soluble CD14 were higher among HIV-infected adults relative to HIV-negative adults (P = .0002, P = .04, and P = .0017, respectively). Further investigation is required to understand drivers of persistent monocyte activation and dysfunction.
Medical subject headings
- Anti-Retroviral Agents
- HIV Infections
- Inflammation
- Monocytes
- Sustained Virologic Response