Determinants of HIV-1 reservoir size and long-term dynamics during suppressive ART.
prospective_cohort · Level II
Where this comes from
- Record sourced from PubMed, PMID 31324762.
- Also identified by DOI 10.1038/s41467-019-10884-9 and PMC identifier 6642170.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
The HIV-1 reservoir is the major hurdle to a cure. We here evaluate viral and host characteristics associated with reservoir size and long-term dynamics in 1,057 individuals on suppressive antiretroviral therapy for a median of 5.4 years. At the population level, the reservoir decreases with diminishing differences over time, but increases in 26.6% of individuals. Viral blips and low-level viremia are significantly associated with slower reservoir decay. Initiation of ART within the first year of infection, pretreatment viral load, and ethnicity affect reservoir size, but less so long-term dynamics. Viral blips and low-level viremia are thus relevant for reservoir and cure studies.
Medical subject headings
- Anti-HIV Agents
- Disease Reservoirs
- HIV Infections
- HIV-1