Two types of functionally distinct Ca<sup>2+</sup> stores in hippocampal neurons.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 31324793.
- Also identified by DOI 10.1038/s41467-019-11207-8 and PMC identifier 6642203.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
It is widely assumed that inositol trisphosphate (IP<sub>3</sub>) and ryanodine (Ry) receptors share the same Ca<sup>2+</sup> pool in central mammalian neurons. We now demonstrate that in hippocampal CA1 pyramidal neurons IP<sub>3</sub>- and Ry-receptors are associated with two functionally distinct intracellular Ca<sup>2+</sup> stores, respectively. While the IP<sub>3</sub>-sensitive Ca<sup>2+</sup> store refilling requires Orai2 channels, Ry-sensitive Ca<sup>2+</sup> store refilling involves voltage-gated Ca<sup>2+</sup> channels (VGCCs). Our findings have direct implications for the understanding of function and plasticity in these central mammalian neurons.
Medical subject headings
- Calcium
- Hippocampus
- ORAI2 Protein
- Pyramidal Cells