circTP63 functions as a ceRNA to promote lung squamous cell carcinoma progression by upregulating FOXM1.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 31324812.
- Also identified by DOI 10.1038/s41467-019-11162-4 and PMC identifier 6642174.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Circular RNAs (circRNAs) are identified as vital regulators in a variety of cancers. However, the role of circRNA in lung squamous cell carcinoma (LUSC) remains largely unknown. Herein, we explore the expression profiles of circRNA and mRNA in 5 paired samples of LUSC. By analyzing the co-expression network of differentially expressed circRNAs and dysregulated mRNAs, we identify that a cell cycle-related circRNA, circTP63, is upregulated in LUSC tissues and its upregulation is correlated with larger tumor size and higher TNM stage in LUSC patients. Elevated circTP63 promotes cell proliferation both in vitro and in vivo. Mechanistically, circTP63 shares miRNA response elements with FOXM1. circTP63 competitively binds to miR-873-3p and prevents miR-873-3p to decrease the level of FOXM1, which upregulates CENPA and CENPB, and finally facilitates cell cycle progression.
Medical subject headings
- Carcinoma, Squamous Cell
- Disease Progression
- Forkhead Box Protein M1
- Gene Expression Regulation, Neoplastic
- RNA, Circular
- Transcription Factors
- Tumor Suppressor Proteins
- Up-Regulation