A zebrafish tale of parabiosis, podocytes, and proteinuria.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 31331464.
- Also identified by DOI 10.1016/j.kint.2019.04.041.
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Abstract
Glomerular damage is a harbinger of kidney dysfunction. Circulating permeability factors are implicated in causing primary and secondary damage to podocytes, leading to proteinuria and eventual progression to the nephrotic syndrome, but the mechanisms are not well understood. Müller-Deile et al. employed parabiosis with zebrafish embryos and found that a damaged glomerulus can impact a healthy one in a shared circulatory system. This methodology shows promise for elucidating kidney injury pathways in response to systemic disease.
Medical subject headings
- Podocytes