Counting the Cuts: MAZTER-Seq Quantifies m<sup>6</sup>A Levels Using a Methylation-Sensitive Ribonuclease.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 31348883.
- Also identified by DOI 10.1016/j.cell.2019.07.006.
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Abstract
Garcia-Campos et al. describe MAZTER-seq, which deploys a sequence-specific, methylation-sensitive bacterial single-stranded ribonuclease MazF to provide nucleotide-resolution quantification of m<sup>6</sup>A methylation sites. The study reveals many new sites and supports the idea of a predictable "m<sup>6</sup>A code," where methylation levels are dictated primarily by local sequence at the site of methylation.
Medical subject headings
- DNA Methylation
- Ribonucleases