Centroid of Age Neighborhoods: A New Approach to Estimate Biological Age.

Abstract

Estimation of human biological age is an important and difficult challenge. Different biomarkers and numerous approaches have been studied for biological age prediction, each with its advantages and limitations. In this paper, we propose a new biological age estimation method, and investigate the performance of the new method. We introduce a centroid based approach, using the notion of age neighborhoods. Specifically, we develop a model, based on which we compute biological age using blood biomarkers, by considering the centroid or mediod of specially selected age neighborhoods. Experiments were performed on the National Health and Human Nutrition Examination Survey dataset with biomarkers (21 451 individuals). Compared with current popular methods for biological age prediction, our experiments show that the proposed age neighborhood model results in an improved performance in human biological age estimation.