Treatment-Related Decisions in Malignant Gliomas: A Feasibility Study.

Abstract

<b><i>Background:</i></b> Glioma patients make frequent decisions regarding treatment and end-of-life care despite cognitive limitations. We evaluated the feasibility of incorporating the Macarthur Competence Assessment Tool for Treatment (MacCAT-T) to assess decision-making ability in glioma patients. <b><i>Methods:</i></b> High-grade glioma patients were consented to an IRB-approved prospective study at one of three treatment decision time points. Patients completed the Montreal Cognitive Assessment (MoCA) and providers informally assessed patient decision-making ability based on neurologic examination. The MacCAT-T, designed to assess patient decision-making domains, was administered by a research assistant. MoCA, provider assessment, and MacCAT-T results were compared to determine whether the MacCAT-T provided additional information. To assess feasibility, we measured administration time and obtained qualitative patient feedback. <b><i>Results:</i></b> Eleven patients (median age = 68 years, median Karnofsky Performance Status [KPS] = 80-90) were enrolled. MacCAT-T administration averaged 18.5 minutes. Ninety percent of patients reported "increased knowledge of their treatment options" after taking the MacCAT-T. Clinicians deemed 10 patients to possess sufficient decision-making ability, yet, 6 of them demonstrated impairments in reasoning on the MacCAT-T. Seven patients yielded discordant MOCA and MacCAT-T data, five patients with MOCA score ≥26 showed qualitative MacCAT-T impairments in <i>Reasoning</i> and five patients who scored <21 were within nonimpaired ranges for three of four decision-making domains. <b><i>Conclusion:</i></b> MacCAT-T administration was feasible and informative to patients but findings were discordant from MOCA and informal provider assessments. The MacCAT-T may help in identifying mild <i>Reasoning</i> impairments related to patients' initial treatment decisions and should be studied further to determine its role in clinical practice.