Calcium: A New Guardian of Naive Pluripotency.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 31374195.
- Also identified by DOI 10.1016/j.stem.2019.07.004.
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Abstract
In this issue of Cell Stem Cell, MacDougall et al. (2019) utilized a CRISPR mutagenesis screen to identify factors for mESC self-renewal and found that intracellular calcium and nuclear export act in naive pluripotency exit. Combined knockout of Tcf7l1 and the calcium transporter Atp2b1 enabled mESCs to self-renew in the absence of LIF and 2i.
Medical subject headings
- Calcium
- Mouse Embryonic Stem Cells