Joint profiling of DNA methylation and chromatin architecture in single cells.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 31384045.
- Also identified by DOI 10.1038/s41592-019-0502-z and PMC identifier 6765429.
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Abstract
We report a molecular assay, Methyl-HiC, that can simultaneously capture the chromosome conformation and DNA methylome in a cell. Methyl-HiC reveals coordinated DNA methylation status between distal genomic segments that are in spatial proximity in the nucleus, and delineates heterogeneity of both the chromatin architecture and DNA methylome in a mixed population. It enables simultaneous characterization of cell-type-specific chromatin organization and epigenome in complex tissues.
Medical subject headings
- Chromatin
- DNA Methylation
- Single-Cell Analysis