AGK Unleashes CD8<sup>+</sup> T Cell Glycolysis to Combat Tumor Growth.
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- Record sourced from PubMed, PMID 31390548.
- Also identified by DOI 10.1016/j.cmet.2019.07.008.
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Abstract
Elevated glycolytic metabolism is essential for CD8+ T cell antitumor function, but cell-intrinsic factors modulating this process remain elusive. In this issue, Hu et al. (2019) show that the lipid kinase acylglycerol kinase (AGK) promotes the glycolytic and functional fitness of CD8+ T cells by inactivating PTEN and boosting mTOR activity, thereby promoting antitumor activity.
Medical subject headings
- CD8-Positive T-Lymphocytes
- Neoplasms