Drug Metabolism as a Community Effort.
other · Level V
Where this comes from
- Record sourced from PubMed, PMID 31390549.
- Also identified by DOI 10.1016/j.cmet.2019.07.005.
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Abstract
Levodopa (L-dopa) is the primary treatment for Parkinson's disease. The gut microbiome can metabolize levodopa, potentially leading to decreased efficacy and side effects, but responsible bacteria were unknown. Maini Rekdal et al. (2019) characterize enzymes in two gut bacteria that sequentially metabolize L-dopa and identify a novel inhibitor that may improve outcomes.
Medical subject headings
- Gastrointestinal Microbiome
- Parkinson Disease