Potential Antigenic Mismatch of the H3N2 Component of the 2019 Southern Hemisphere Influenza Vaccine.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 31400756.
- Also identified by DOI 10.1093/cid/ciz723 and PMC identifier 7245157.
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Abstract
Here, we find that the egg-adapted H3N2 component of the 2019 Southern Hemisphere influenza vaccine elicits an antibody response in ferrets that is highly focused on antigenic site A of hemagglutinin. This is potentially problematic as most H3N2 viruses currently circulating in the Southern Hemisphere possess antigenic site A substitutions.
Medical subject headings
- Influenza Vaccines
- Influenza, Human