Twist of Fate for Acute Promyelocytic Leukemia: TRIB3-TWIST1 Interaction Promotes Resistance.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 31405833.
- Also identified by DOI 10.1158/1078-0432.CCR-19-2140 and PMC identifier 6801084.
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Abstract
While acute promyelocytic leukemia has a good prognosis with all-trans retinoic acid (ATRA) treatment, ATRA resistance is a major obstacle. It is now demonstrated that TRIBBLES 3 (TRIB3) stabilizes TWIST1, leading to ATRA resistance. Peptides that disrupt this interaction lead to the degradation of TWIST1 and overcome ATRA resistance.<i>See related article by Lin et al., p. 6228</i>.
Medical subject headings
- Leukemia, Promyelocytic, Acute