Tuberculosis Antigen-Specific T-Cell Responses During the First 6 Months of Antiretroviral Treatment.
prospective_cohort · Level II
Where this comes from
- Record sourced from PubMed, PMID 31419285.
- Also identified by DOI 10.1093/infdis/jiz417 and PMC identifier 6910879.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
The reconstitution of Mycobacterium tuberculosis antigen-specific CD4 T cells in a cohort of HIV-infected persons starting antiretroviral treatment (ART) in a high tuberculosis endemic area is described. Restoration of the antigen-specific CD4 T-cell subsets mirrored the overall CD4 T-cell compartment. Activation (assessed by HLA-DR expression) decreased during ART but remained elevated compared to HIV-uninfected persons. Despite known M. tuberculosis sensitization determined by interferon-γ release assay, 12/23 participants had no M. tuberculosis-specific CD4 T cells detectable by flow cytometry, combined with overall elevated T-cell activation and memory differentiation, suggesting heightened turnover. Our data suggest early ART initiation to maintain polyfunctional immune memory responses.
Medical subject headings
- Anti-HIV Agents
- CD4-Positive T-Lymphocytes
- HIV Infections
- Latent Tuberculosis
- Mycobacterium tuberculosis