Mammalian Mediator as a Functional Link between Enhancers and Promoters.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 31442397.
- Also identified by DOI 10.1016/j.cell.2019.07.040.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
In this issue of Cell, Casellas and colleagues provide insights into the structural and functional aspects of the mammalian multi-subunit Mediator complex, a conserved and essential transcriptional coregulator. Combining cryo-EM, genetic, and genomic analyses, the work sheds light on Mediator's mode of action as a functional bridge between enhancers and promoters.
Medical subject headings
- Mediator Complex