Low-Level Inhibition of Hsp90 Forces Cells to Tip Their (Antigenic) Hand.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 31444251.
- Also identified by DOI 10.1158/1078-0432.CCR-19-2094 and PMC identifier 6825573.
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Abstract
Low-level inhibition of hsp90 enhances the antigenicity of cells whereas high-level inhibition diminishes antigenicity. The mechanism(s) by which hsp90 determines antigenicity are only partially clear. Regardless, these observations have profound implications in protein trafficking and antigen presentation and suggest a novel way to enhance the potency of existing anticancer agents.<i>See related article by Jaeger et al., p. 6392</i>.
Medical subject headings
- Antigen Presentation
- Neoplasms