Cellular regeneration of podocytes from parietal cells: the debate is still open.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 31445579.
- Also identified by DOI 10.1016/j.kint.2019.04.038.
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Abstract
The study by Kaverina et al. in this issue addresses an important question: can podocytes be replenished by parietal epithelial cells (PECs)? The authors use a complex transgenic mouse model in which podocytes are labeled with GFP and PECs are simultaneously labeled with tdTomato. When Kaverina and colleagues induce focal segmental glomerulosclerosis (FSGS), they find that individual PECs are doubly labeled, coexpress podocyte markers, and form structures similar to foot processes, suggesting that these PECs may have transdifferentiated into podocytes.
Medical subject headings
- Glomerulosclerosis, Focal Segmental
- Podocytes