IL-12/IL-23 neutralization is ineffective for alopecia areata in mice and humans.
other · Level V
Where this comes from
- Record sourced from PubMed, PMID 31470035.
- Also identified by DOI 10.1016/j.jaci.2019.08.014 and PMC identifier 6900443.
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Abstract
Ustekinumab is currently being explored for the treatment of alopecia areata. Here, our work in a murine model and in human patients indicates that neutralization of the IL-12 and IL-23 pathways does not ameliorate disease.
Medical subject headings
- Alopecia
- Antibodies, Neutralizing
- Interleukin-12 Subunit p40
- Interleukin-23 Subunit p19