Biological imaging of chemical bonds by stimulated Raman scattering microscopy.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 31471618.
- Also identified by DOI 10.1038/s41592-019-0538-0.
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Abstract
All molecules consist of chemical bonds, and much can be learned from mapping the spatiotemporal dynamics of these bonds. Since its invention a decade ago, stimulated Raman scattering (SRS) microscopy has become a powerful modality for imaging chemical bonds with high sensitivity, resolution, speed and specificity. We introduce the fundamentals of SRS microscopy and review innovations in SRS microscopes and imaging probes. We highlight examples of exciting biological applications, and share our vision for potential future breakthroughs for this technology.
Medical subject headings
- Macromolecular Substances
- Molecular Imaging
- Nonlinear Optical Microscopy