Microglia Metabolic Breakdown Drives Alzheimer's Pathology.
other · Level V
Where this comes from
- Record sourced from PubMed, PMID 31484050.
- Also identified by DOI 10.1016/j.cmet.2019.08.017.
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Abstract
Altered metabolic function is common in stressed immune cells, but alteration in brain microglia during neurodegeneration is not understood. In this issue, Baik et al. (2019) provide insight into microglial metabolism. They demonstrate a switch from oxidative phosphorylation to glycolysis following interaction with amyloid beta acutely, and breakdown in both pathways chronically.
Medical subject headings
- Alzheimer Disease