Changing the Rules of the Game: How Winners Become Losers during Oncogenic Cell Selection.
editorial · Level V
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- Record sourced from PubMed, PMID 31491391.
- Also identified by DOI 10.1016/j.stem.2019.08.006.
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Abstract
As we age, our tissues become a mosaic of random mutations, many of which are oncogenic and promote the expansion of their carrier cells. In this issue of Cell Stem Cell, Fernandez-Antoran et al. (2019) show how commonly used medical procedures modify cell selection dynamics to either expand or eliminate cells carrying oncogenic p53 mutations.
Medical subject headings
- Oncogenes
- Tumor Suppressor Protein p53