Understanding the kidney one cell at a time.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 31492507.
- Also identified by DOI 10.1016/j.kint.2019.03.035 and PMC identifier 6777841.
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Abstract
A revolution in cellular measurement technology is underway. Whereas prior studies have been able to analyze only the averaged outputs from renal tissue, we now can accurately monitor genome-wide gene expression, regulation, function, cellular history, and cellular interactions in thousands of individual cells in a single experiment. These methods are key drivers in changing our previous morphotype-based organ and disease descriptions to unbiased genomic definitions and therefore improving our understanding of kidney development, homeostasis, and disease.
Medical subject headings
- Epigenomics
- Kidney
- Kidney Diseases
- Single-Cell Analysis