Colloidal stability versus self-assembly of nanoparticles controlled by coiled-coil protein interactions.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 31498366.
- Also identified by DOI 10.1039/c9sm01314h and PMC identifier 6760969.
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Abstract
Orientational discrimination of biomolecular recognition is exploited here as a molecular engineering tool to regulate nanoparticle self-assembly or stability. Nanoparticles are conjugated with the heterodimerizing coiled-coils, A and B, which associate in parallel orientation. Simply flipping the orientation of one coiled-coil results in either self-assembling or colloidally stable nanoparticles.
Medical subject headings
- Gold
- Metal Nanoparticles
- Proteins