Endothelial Cell Development and Its Application to Regenerative Medicine.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 31518171.
- Also identified by DOI 10.1161/CIRCRESAHA.119.311405 and PMC identifier 8109152.
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Abstract
The formation and remodeling of a functional circulatory system is critical for sustaining prenatal and postnatal life. During embryogenesis, newly differentiated endothelial cells require further specification to create the unique features of distinct vessel subtypes needed to support tissue morphogenesis. In this review, we explore signaling pathways and transcriptional regulators that modulate endothelial cell differentiation and specification, as well as applications of these processes to stem cell biology and regenerative medicine. We also summarize recent technical advances, including the growing utilization of single-cell sequencing to study vascular heterogeneity and development.
Medical subject headings
- Endothelial Progenitor Cells
- Endothelium, Vascular
- Neovascularization, Physiologic
- Regenerative Medicine