Mesenchymal stem versus stromal cells: International Society for Cell & Gene Therapy (ISCT®) Mesenchymal Stromal Cell committee position statement on nomenclature.
expert_opinion · Level V
Where this comes from
- Record sourced from PubMed, PMID 31526643.
- Also identified by DOI 10.1016/j.jcyt.2019.08.002.
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Abstract
The International Society for Cell & Gene Therapy (ISCT®) Mesenchymal Stromal Cell (ISCT MSC) committee offers a position statement to clarify the nomenclature of mesenchymal stromal cells (MSCs). The ISCT MSC committee continues to support the use of the acronym "MSCs" but recommends this be (i) supplemented by tissue-source origin of the cells, which would highlight tissue-specific properties; (ii) intended as MSCs unless rigorous evidence for stemness exists that can be supported by both in vitro and in vivo data; and (iii) associated with robust matrix of functional assays to demonstrate MSC properties, which are not generically defined but informed by the intended therapeutic mode of actions.
Medical subject headings
- Cell- and Tissue-Based Therapy
- Genetic Therapy
- Mesenchymal Stem Cells
- Stromal Cells
- Terminology as Topic