Gastroesophageal reflux GWAS identifies risk loci that also associate with subsequent severe esophageal diseases.
meta_analysis · Level I
Where this comes from
- Record sourced from PubMed, PMID 31527586.
- Also identified by DOI 10.1038/s41467-019-11968-2 and PMC identifier 6746768.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Gastroesophageal reflux disease (GERD) is caused by gastric acid entering the esophagus. GERD has high prevalence and is the major risk factor for Barrett's esophagus (BE) and esophageal adenocarcinoma (EA). We conduct a large GERD GWAS meta-analysis (80,265 cases, 305,011 controls), identifying 25 independent genome-wide significant loci for GERD. Several of the implicated genes are existing or putative drug targets. Loci discovery is greatest with a broad GERD definition (including cases defined by self-report or medication data). Further, 91% of the GERD risk-increasing alleles also increase BE and/or EA risk, greatly expanding gene discovery for these traits. Our results map genes for GERD and related traits and uncover potential new drug targets for these conditions.
Medical subject headings
- Esophageal Diseases
- Gastroesophageal Reflux
- Genome-Wide Association Study