Oseltamivir Resistance in Severe Influenza A(H1N1)pdm09 Pneumonia and Acute Respiratory Distress Syndrome: A French Multicenter Observational Cohort Study.
prospective_cohort · Level II
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- Record sourced from PubMed, PMID 31538643.
- Also identified by DOI 10.1093/cid/ciz904.
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Abstract
In a multicenter cohort study including 22 oseltamivir-treated patients with influenza A(H1N1)pdm09 acute respiratory distress syndrome, prevalence of the H275Y substitution in the neuraminidase, responsible for highly reduced sensitivity to oseltamivir, was 23%. Patients infected with the H275Y mutant virus had higher day 28 mortality than others (80% vs 12%; P = .011).
Medical subject headings
- Influenza A Virus, H1N1 Subtype
- Influenza, Human
- Pneumonia
- Respiratory Distress Syndrome