FGF23 and inflammation-a vicious coalition in CKD.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 31543148.
- Also identified by DOI 10.1016/j.kint.2019.05.018.
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Abstract
High serum concentrations of the phosphaturic hormone, fibroblast growth factor 23 (FGF23), contribute to various tissue injuries. In chronic kidney disease, the sources of FGF23 and the stimuli that control FGF23 production differ from those in the physiologic scenario. Mediators of inflammation are intensively studied as potential factors that contribute to FGF23 elevations and thereby might function as drug targets to lower FGF23 levels. The present study focuses on tumor necrosis factor.
Medical subject headings
- Hypophosphatemia, Familial
- Renal Insufficiency, Chronic