Surface-kinetics mediated mesoporous multipods for enhanced bacterial adhesion and inhibition.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 31558724.
- Also identified by DOI 10.1038/s41467-019-12378-0 and PMC identifier 6763480.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Despite the importance of nanoparticle's multipods topology in multivalent-interactions enhanced nano-bio interactions, the precise manipulation of multipods surface topological structures is still a great challenge. Herein, the surface-kinetics mediated multi-site nucleation strategy is demonstrated for the fabrication of mesoporous multipods with precisely tunable surface topological structures. Tribulus-like tetra-pods Fe<sub>3</sub>O<sub>4</sub>@SiO<sub>2</sub>@RF&PMOs (RF = resorcinol-formaldehyde resin, PMO = periodic mesoporous organosilica) nanocomposites have successfully been fabricated with a centering core@shell Fe<sub>3</sub>O<sub>4</sub>@SiO<sub>2</sub>@RF nanoparticle, and four surrounding PMO nanocubes as pods. By manipulating the number of nucleation sites through mediating surface kinetics, a series of multipods mesoporous nanocomposites with precisely controllable surface topological structures are formed, including Janus with only one pod, nearly plane distributed dual-pods and tri-pods, three-dimensional tetrahedral structured tetra-pods, etc. The multipods topology endows the mesoporous nanocomposites enhanced bacteria adhesion ability. Particularly, the tribulus-like tetra-pods mesoporous nanoparticles show ~100% bacteria segregation and long-term inhibition over 90% after antibiotic loading.
Medical subject headings
- Bacterial Adhesion
- Formaldehyde
- Nanocomposites
- Nanoparticles
- Resorcinols