Genome-wide association study reveals dynamic role of genetic variation in infant and early childhood growth.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 31575865.
- Also identified by DOI 10.1038/s41467-019-12308-0 and PMC identifier 6773698.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Infant and childhood growth are dynamic processes with large changes in BMI during development. By performing genome-wide association studies of BMI at 12 time points from birth to eight years (9286 children, 74,105 measurements) in the Norwegian Mother, Father, and Child Cohort Study, replicated in 5235 children, we identify a transient effect in the leptin receptor (LEPR) locus: no effect at birth, increasing effect in infancy, peaking at 6-12 months (rs2767486, P<sub>6m</sub> = 2.0 × 10<sup>-21</sup>, β<sub>6m</sub> = 0.16 sd-BMI), and little effect after age five. We identify a similar transient effect near the leptin gene (LEP), peaking at 1.5 years (rs10487505, P<sub>1.5y</sub> = 1.3 × 10<sup>-8</sup>, β<sub>1.5y</sub> = 0.079 sd-BMI). Both signals are protein quantitative trait loci for soluble-LEPR and LEP in plasma in adults independent from adult traits mapped to the respective genes, suggesting key roles of common variation in the leptin signaling pathway for healthy infant growth.
Medical subject headings
- Genetic Variation
- Genome-Wide Association Study
- Genomics
- Receptors, Leptin