Auto-Regulation of Leptin Neurobiology.
Level V
Where this comes from
- Record sourced from PubMed, PMID 31577926.
- Also identified by DOI 10.1016/j.cmet.2019.09.006 and PMC identifier 7413296.
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Abstract
The clinical use of the hormone leptin, a key regulator of food intake, to treat the most common instances of obesity has so far failed. In this issue, Zhao et al. (2019) report that, paradoxically, reducing leptin levels in obese mice increases their sensitivity to the concentrations that remain, and leads to reductions in weight gain, thus suggesting why these earlier trials may have failed and possibly a new approach to treating obesity.
Medical subject headings
- Leptin
- Weight Loss