United They Stand, Divided They Fall.

Harris, Isaac S; Brugge, Joan S · Cell Metab · 2019

editorial · Level V

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Abstract

Cancer cells that leave their natural environment during metastatic spread must adapt to numerous stresses to survive. In this issue, Labuschagne et al. (2019) highlight one adaptive mechanism to overcome these stresses that involves cell clustering, which induces a hypoxic environment and metabolic rewiring to buffer oxidative stress.

Medical subject headings