Substrates of PHD.
Level V
Where this comes from
- Record sourced from PubMed, PMID 31577931.
- Also identified by DOI 10.1016/j.cmet.2019.08.008 and PMC identifier 7454164.
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Abstract
The discovery of prolyl hydroxylase domain proteins (PHDs) as key enzymes in the hypoxia inducible factor (HIF) pathway has been followed by reports of a multitude of non-HIF substrates of PHD. Reporting in eLife, Cockman et al. (2019) find a surprising lack of detectable PHD activity toward any of them.
Medical subject headings
- Ankyrin Repeat
- Proteomics