Endogenous stimulus-powered antibiotic release from nanoreactors for a combination therapy of bacterial infections.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 31578336.
- Also identified by DOI 10.1038/s41467-019-12233-2 and PMC identifier 6775118.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
The use of an endogenous stimulus instead of external trigger has an advantage for targeted and controlled release in drug delivery. Here, we report on cascade nanoreactors for bacterial toxin-triggered antibiotic release by wrapping calcium peroxide (CaO<sub>2</sub>) and antibiotic in a eutectic mixture of two fatty acids and a liposome coating. When encountering pathogenic bacteria in vivo these nanoreactors capture the toxins, without compromising their structural integrity, and the toxins form pores. Water enters the nanoreactors through the pores to react with CaO<sub>2</sub> and produce hydrogen peroxide which decomposes to oxygen and drives antibiotic release. The bound toxins reduce the toxicity and also stimulate the body's immune response. This works to improve the therapeutic effect in bacterially infected mice. This strategy provides a Domino Effect approach for treating infections caused by bacteria that secrete pore-forming toxins.
Medical subject headings
- Anti-Bacterial Agents
- Bacterial Infections
- Combined Modality Therapy
- Nanostructures
- Nanotechnology