Smelling Danger: Olfactory Stem Cells Control Immune Defense during Chronic Inflammation.

Rustenhoven, Justin; Kipnis, Jonathan · Cell Stem Cell · 2019

editorial · Level V

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Abstract

Neurogenesis is critical to continuously replacie olfactory neurons but is impaired during chronic inflammatory rhinosinusitis. In this issue of Cell Stem Cell, Chen et al. (2019) describe the inflammation-induced switching of olfactory stem cells from a regenerative phenotype to one participating in immune defense; this process contributes to deficient replacement of olfactory sensory neurons.

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