Collisions on the Busy DNA Highway Set Up Barriers for Reprogramming.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 31585090.
- Also identified by DOI 10.1016/j.stem.2019.09.007.
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Abstract
Why most cells remain refractory to transcription factor (TF)-induced fate conversion remains largely mysterious, with the answers holding important instructions on how to effectively direct cell identities. In this issue of Cell Stem Cell, Babos et al. (2019) show that conflicts caused by simultaneous high transcription and high replication rates are to blame.
Medical subject headings
- Cellular Reprogramming
- DNA