Cases in Precision Medicine: APOL1 and Genetic Testing in the Evaluation of Chronic Kidney Disease and Potential Transplant.
Level V
Where this comes from
- Record sourced from PubMed, PMID 31590185.
- Also identified by DOI 10.7326/M19-1389 and PMC identifier 7441647.
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Abstract
This article discusses potential indications for genetic testing in an African American patient with chronic kidney disease who is being evaluated for a kidney transplant. Two known risk variants in the APOL1 (apolipoprotein L1) gene predispose to kidney disease and are found almost exclusively in persons of African ancestry. APOL1 risk variants are considered, including whether clinicians should incorporate genetic testing in the screening process for living kidney donors. In addition to APOL1 testing, the role of diagnostic exome sequencing in evaluating potential transplant recipients and donors with a positive family history of kidney disease is discussed.
Medical subject headings
- Apolipoprotein L1
- Genetic Testing
- Kidney Transplantation
- Precision Medicine
- Renal Insufficiency, Chronic