The effects of long non-coding ribonucleic acids on various cellular components in rheumatoid arthritis.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 31605483.
- Also identified by DOI 10.1093/rheumatology/kez472 and PMC identifier 6909907.
- Licence recorded as CC BY-NC.
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Abstract
RA is a chronic, autoimmune-mediated inflammatory pathology. Long non-coding RNAs (lncRNAs) are a novel group of non-coding RNAs with a length of >200 nucleotides. There are reports emerging that suggest that lncRNAs participate in establishing and sustaining autoimmune diseases, including RA. In this review article, we highlight the functions of lncRNAs in different cell types in RA. Our review indicates that lncRNAs affect various cellular components and are novel candidates that could constitute promising targets for the diagnosis and treatment of RA.
Medical subject headings
- Arthritis, Rheumatoid
- Fibroblasts
- Leukocytes, Mononuclear
- RNA, Long Noncoding
- T-Lymphocytes