Roles of Regulatory T Cells in Tissue Pathophysiology and Metabolism.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 31607562.
- Also identified by DOI 10.1016/j.cmet.2019.09.010 and PMC identifier 7657366.
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Abstract
Regulatory T (Treg) cells expressing the X-chromosome-encoded transcription factor Foxp3 represent a specialized immunosuppressive lineage with a well-recognized, essential function in preventing fatal autoimmunity and inflammation. Recent studies revealed that Treg cells can also exert systemic effects on metabolism and partake in tissue repair, suggesting a dual role for these cells in serving and protecting tissues. Here, we review multiple means by which Treg cells support tissue function and organismal homeostasis.
Medical subject headings
- Adaptive Immunity
- Autoimmunity
- Forkhead Transcription Factors
- Inflammation
- T-Lymphocytes, Regulatory